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Background
(1‐3)‐b‐D‐glucan (BDG) is a fungal cell wall component and, in the absence of invasive fungal infection, a novel biomarker for microbial translocation of endogenous fungal products from the gastrointestinal tract into systemic circulation. However, its value as a marker of fungal translocation is limited by a concern that plant BDG‐rich food influences blood BDG levels.
Methods
We conducted...
Objectives
With the outbreak of coronavirus disease 2019 (COVID‐19), clinicians have used personal protective equipment to avoid transmission of severe acute respiratory syndrome coronavirus 2. However, they still face occupational risk of infection, when treating COVID‐19 patients. This may be highest during invasive diagnostic procedures releasing aerosols and droplets. Thereby, the use of diagnostic...
Cryptococcosis is a serious and sometimes fatal fungal disease caused by Cryptococcus species. Worldwide, it is estimated to kill over 180 000 annually, with 75% of deaths occurring in sub‐Saharan Africa. Though cryptococcal infections are rare in otherwise healthy individuals, there have been reported cases in immunocompetent persons. Most cases occur in individuals who have weakened immune systems,...
Background
Trichosporon asahii is the major causative agent of disseminated and deep‐seated trichosporonosis. It is capable of forming biofilms on surfaces, leading to medical device‐related infection.Trichosporon asahii may be present as yeast form, hyphae and/or arthroconidia; however, the relationship between its biofilm‐forming ability and its morphological transition is unclear.
Objectives...
Background
Whether allergic bronchopulmonary aspergillosis (ABPA) affects maternal and perinatal outcomes during pregnancy or vice versa is unknown.
Objective
To evaluate the course of ABPA and its consequence on maternal and perinatal outcomes during pregnancy.
Methods
We retrospectively included pregnant women with ABPA (cases) and compared them with non‐pregnant ABPA subjects (controls). We...
Chromoblastomycosis (CBM) is a chronic granulomatous fungal infection caused by melanised or brown‐pigmented fungi. It can lead to chronic persistent infections and may cause incapacity for labour in some severe clinical forms. The optimal therapy for CBM is still uncertain. Here, we reported the case of a 66‐year‐old male who has had red plaque and recurrent keratinised protrusions on his right forearm...
Background
The emergence of azole resistance in non‐fumigatus Aspergillus strains is on the raise.
Objectives
To study the susceptibility profiles and the molecular mechanisms of azole resistance of environmental and clinical strains of Aspergillus flavus from Argentina.
Methods
Thirty‐five A flavus isolates (18 from soybean seeds and chickpea seeds and 17 from the clinic) were analysed for amphotericin...
Background
The aim of this study was to estimate the incidence of and risk factors for Pneumocystis pneumonia (PCP) infection in diffuse large B‐cell lymphoma (DLBCL) patients treated with rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (R‐CHOP).
Methods
The medical records of 739 DLBCL patients who received R‐CHOP between May 2004 and January 2019 were retrospectively...
Introduction
A multi‐centre study to determine the outcomes and risks for invasive fungal disease (IFD) in myeloma (MM) patients treated with second‐generation immunomodulatory drugs, proteasome inhibitors and monoclonal antibodies was conducted.
Methods
Clinical and microbiology records were reviewed to capture patient demographics, disease characteristics, treatment, IFD episodes and outcomes...
Background
Invasive mould diseases are associated with high morbidity, mortality and economic impact. Its treatment is often started prior to differential pathogen diagnosis. Isavuconazole is approved for treatment of invasive aspergillosis (IA) and invasive mucormycosis (IM) when amphotericin‐B is not indicated.
Objectives
To estimate the cost‐effectiveness of isavuconazole vs voriconazole for...
Background
In recent years, methylene blue mediated‐photodynamic therapy (MB‐PDT) has proved to be an effective inhibitor to a variety of microorganisms, including Trichophyton rubrum, the most common dermatophyte worldwide. However, previous studies mainly focused on the spore form of T rubrum, but rarely on its hyphal form, although the latter is the main pathogenic form of T rubrum in vivo.
...
Background
Isavuconazole (ISA) is a frequently used antifungal agent for the treatment of invasive fungal diseases (IFDs). However, hospital reimbursement data for ISA is limited.
Objectives
The primary objective of this study was to analyse the different perspectives of relevant stakeholders and the (dis)incentives for the administration of ISA in Germany. To that aim, the health economic effects...
Background
Treatment of Candida albicans bloodstream infection with fluconazole is associated with significant mortality despite in vitro susceptibility to the drug.
Objectives
We sought to determine whether tolerance to fluconazole is predictive of treatment failure.
Methods
We reviewed patients with monomicrobial C albicans bloodstream infection who received primary monotherapy with fluconazole...
Background
As the global coronavirus pandemic (COVID‐19) spreads across the world, new clinical challenges emerge in the hospital landscape. Among these challenges, the increased risk of coinfections is a major threat to the patients. Although still in a low number, due to the short time of the pandemic, studies that identified a significant number of hospitalised patients with COVID‐19 who developed...
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